Tuesday, 12th November ESA-SRB-ANZBMS 2024 in conjunction with ENSA

With recent launches and approvals across Europe and the US, palopegteriparatide is a novel treatment option for patients suffering from hypoparathyroidism who would benefit from having their parathyroid hormone (PTH) restored to physiological levels. Join us for a comprehensive presentation and panel discussion to hear from both international and local experts on the potential impact and timing of this treatment option for Australian patients.

Confirmed Speakers: A/Prof. Cherie Chiang, Prof. Aliya Khan of McMaster University in Canada & Prof. David Torpy of Royal Adelaide Hospital, SA.

Breakfast is included as part of this session outside the room.

Research has shown that osteoanabolic treatments work best in patients who haven't had prior treatment for osteoporosis and are less effective after antiresorptive therapy. With romosozumab about to be listed on the PBS for first-line treatment post-fracture in very high-risk patients, it's appropriate to examine the clinical evidence supporting this new approach.

Confirmed Speaker: Prof Peter R Ebeling AO   

Breakfast is included as part of this session outside the room.

This joint ESA/SRB/ANZBMS session aims to promote discussions about the benefits of foundational research, alternative models and unexpected discoveries, together with strategies to address the challenges faced by the research scientists in our societies. The session will feature a speaker from each society, followed by a panel and audience discussion. Breakfast is included, and both scientists and clinicians are encouraged to attend.

Presenters include:

• Wayne Tilley (ESA)
• Patrick Western (SRB)
• Michelle McDonald (ANZBMS)

Breakfast is included as part of this session outside the room.

• Research Scientists Breakfast Session - Saving an endangered species - Michelle McDonald

• Bone and Blood Interactions in the Bone Marrow Microenvironment - Joy Wu

• From pulses to flushes: a journey through reproductive life - Bronwyn Stuckey

• Unveiling oocyte and embryo developmental potential with advanced photonics - Kylie Dunning

• Chronic kidney Disease and Bone Health; ‘Mind the Gap’. - Grahame Elder

• FOXL2 interaction with different binding partners regulates the dynamics of ovarian development  - Roberta Migale

• Calcium disorders including management of hypoparathyroidism and hypercalcaemia - Heide Siggelkow

• Beyond the break: how multimorbidity drives up refracture and mortality rates in low-trauma fracture cases in Australia - Mike Lin
• GWAS meta-analysis of bone stiffness indices in 544,864 individuals identifies new candidate genes that may control the structural integrity of bone and susceptibility to fracture. - Kaitlyn A Flynn

• Region-specific increase in cortical porosity in the adult murine skeleton by inducing STAT3 hyperactivation in osteoblasts and osteocytes - Natalie YY Koh

• Glucocorticoids induce neurogenic heterotopic ossifications after spinal cord injury - Kylie A Alexander
• Automated abdominal aortic calcification scores on bone density machine-derived images and atherosclerotic cardiovascular disease: The UK Biobank Imaging Study - Joshua R Lewis

• Autoimmune thyroid disease and thyroid cancer - JEEHEE YOON
• Current practices and updated KTA guidelines for RAI treatment of Graves’ disease in Korea - Kyeong Jin Kim
• THYRO pilot: lesions from design and completion of a feasibility trial for combination hypothyroidism treatment - Donald McLeod

• Meal timing as an intervention to combat obesity and associated metabolic disorders. - Leonie Heilbronn
• GLP1R-based anti-obesity medications regulate the mesolimbic dopamine system - Zane Andrews
• The Nutritional Management of Obesity - Gary Wittert
• Practical approach to obesity management - Samantha Hocking

• Dysregulated Iron Transport and Haemoglobin Synthesis Pathways in Fetal Growth Restriction Placentae - Veronica B Botha
• TLR3 activation in the peri-implantation period impairs mid-gestation decidual artery remodelling and placental efficiency impacting fetal growth and offspring phenotype - Stacey J Savin
• Targeted lipid nanoparticle delivery of short interfering RNA to treat preeclampsia - Maya J Robertson
• Angiotensin-converting enzyme 2 is a novel protector against repeated placental hypoxia and reoxygenation insult - India A Brooker
• Do adenosine receptors play a role in placentation and placental dysfunction? - Rose C Freemantle
• Pregnancy zone protein as a novel regulator of hypertension during pregnancy via interaction with chymase - Demi K Georgiou

DATE: Tuesday 12th November

TIME:12:30pm - 1:30pm

VENUE: Hall B

Lunch will be provided in foyer outside this room for attendees.

Join the Future Science Talks team who will help transform your presentation skills.

• Learn 2-3 effective comedy techniques to captivate your audience within the first 30 seconds and build instant rapport.
• Discover the reverse pyramid concept, a powerful tool for simplifying complex information.
• Gain valuable script-writing tips, including structuring presentations and effective writing strategies.

This session is packed with practical insights. Participants will also receive a comprehensive handout with how-to guides on comedy and script writing, ensuring you can apply the material with confidence. Don't miss this opportunity to enhance your communication skills.

Crysvita (burosumab) was first approved in Australia in September 2021 for the treatment of X-linked hypophosphataemia (XLH) in adults, adolescents and children 1 year of age or older. PBS listing followed in November 2022, with more than 200 XLH patients now receiving the treatment. Join us to hear about the Australian experience so far. Experts in the field will discuss their collective experience and highlight specific patient observations using a case-based approach.

Confirmed Speaker: Prof. Margaret Zaccharin, OA, Royal Children's Hospital, VICA/Prof. Christian Girgis, Westmead Hospital, NSW, Dr Shejil Kumar, Royal North Shore Hospital, NSW

Chairperson/s: Prof. Peter Ebeling, OA, Monash Health, VIC    

Lunch will be provided in foyer outside this room for attendees.

• The Link Between Testosterone and Sex Hormone-Binding Globulin with Physical Function and Body Composition in People with and without Type 2 Diabetes - Rhiannon Healy
• Mass spectrometric analysis of corticosteroid binding globulin (CBG) in septic shock patients - Jessica (Hee Jong) Lee
• Identification of aldosterone-producing adrenal adenomas using novel nuclear imaging - Elisabeth Ng
• Pituitary tumour outcomes are associated with histological type, proliferative indices, invasiveness, PTTG and MSH6 - Nele Lenders
• Tolvaptan versus fluid restriction in hospital inpatients with moderate-profound hyponatraemia 115-130 mmol/L: An open-label, randomised, clinical trial - Annabelle M Warren
• Nox5 in human peripheral blood mononuclear cells: a potential prognostic biomarker in unstable diabetic coronary artery disease - Tomasz J Block

• TGFβ signalling links the genetic and fetal origins of a predisposition to polycystic ovary syndrome. - Ray Rodgers
• Intrauterine neuroimmune modulation of the Uterus-Brain Axis - Susan Evans
• Development of a new form of IVM and path to clinical application - Robert Gilchrist
• Evidence-based care for managing menopause: A NICE Guidelines Update - Martha Hickey

• PRC2 safeguards granulosa cell identity and promotes proliferation to support ovarian folliculogenesis - Ellen G Jarred
• A proteomic signature of mouse oocyte developmental competence gained from in vivo and in vitro systems - Emily R Frost
• Cardiac troponin I TNNI3 is a contemporary pregranulosa cell marker of primordial follicle activation. - Jessie M Sutherland
• Nursing Nutrition: The impact of maternal diet on offspring health  - Zaahida S Abdul Jalil
• Zincing outside the box: in vitro bovine embryo development by zinc chelation - Rhiannon J Gurkin
• Species differences in the synthesis and activity of growth differentiation factor-9 and bone morphogenetic protein-15 - Lara E Griffin-Krenn
• The effect of nicotinic acid supplementation on NAD+ metabolite concentrations in follicular fluid and serum of aged mares: Can we reverse the age associated decline in oocyte quality? - Laura-Anne R Good
• Understanding mechanisms of Atrazine induced damage in the ovary - Ngoc Tho Tony Nguyen

• Impact of digital holographic microscopy on the viability of the preimplantation embryo - Battice N Westendorp
• The probability of pregnancy occurring following laparoscopic artificial insemination of sheep - Eloise A Spanner
• Impact of MHC exposure during intercourse on future fertility within mice - Laura Wilkinson
• Utilising multi-omics of mouse uterine fluid across post-implantation stages of gestation to inform the design of ex-utero culture media - Ben M Lawrence
• Unveiling paternal inheritance beyond DNA: sperm miR-30a shapes early embryo development - Oluwabunmi Olatunji
• Untangling cryopreservation from biopsy: Effects of repeated cryopreservation alone on embryo viability and post-transfer outcomes - Tong Li
• High resolution ultrasound provides new insights into the rapid embryonic development of marsupials - Brandon R Menzies
• Investigating the effects of prolonged culture on antioxidant capacity in commercially available insemination media and its impact on protecting spermatozoa against oxidative stress - Emma M Pyneandee

• The bone in myeloma – exploring complex cellular interactions and discovering biomarkers of disease - Melissa Cantley
• Bone Health and Cancer Management - Peter Wong
• A 'Young' Man's new life without Testosterone.  - Will McDonald
• Cognitive Decline and Fracture risk in Elderly Men: The Osteoporotic Fractures in Men (MrOS) Study - Dima A Alajlouni
• TNFα inhibition accelerates rebound bone loss following withdrawal of RANKL inhibition. - Michelle McDonald
• Low bone mineral density is associated with increased risk of post-fracture mortality - Nick Tran
• Bone marrow neutrophil precursors inhibit osteoclast differentiation in vivo and in vitro - Blessing Crimeen-Irwin

• Turner Syndrome – chronic disease management and reproductive health in adulthood - Amanda Vincent
• Klinefelter syndrome: more than hypogonadism - Sarah Catford
• Congenital adrenal hyperplasia, paediatric to adult care     - David J. Torpy
• Transition from Paediatric to Adult Care Dream, nightmare or success? - Margaret Zacharin

• Targeting PUMA for fertility preservation against chemotherapy-induced ovarian damage - Lauren R Alesi
• COL1A2 is down-regulated in early pregnancy placenta from term preeclampsia and is associated with disrupted angiogenesis - Sarvenaz Sabourirad
• Activin A modulates the pace of murine germ cell development and promotes a niche that supports spermatogonial stem cell self-renewal - Penny Whiley
• Single-cell analysis of fertile and infertile endometrial epithelial organoids identified novel genes associated with endometrial receptivity - Michaela Sacco
• Viewing early life without labels: optical approaches for imaging the early embryo - Darren JX Chow
• Is lipid damage the key? Exploring Arachidonate 15-lipoxygenase (ALOX15) as a molecular conduit between infertility and systemic ill health in male mice - Nathan D Burke

• Developing Histomic Signatures in Papillary Thyroid Cancer: Can Machine Learning Algorithms Predict Genotypes? - Matti Gild
• The Utility of ⁶⁸Ga-DOTATATE and ¹⁸F-FDG PET/CT in Predicting the Response to Tyrosine Kinase Inhibitors in Patients with Advanced Medullary Thyroid Cancer. - James McNeil
• A new indication for BRAF testing: identification of the V600E variant to revise the diagnosis of Rathke’s cleft cyst to papillary craniopharyngioma - Edward Mignone
• A Prospective Analysis of TERT Promoter Mutations and Initial Therapy Response in Papillary Thyroid Cancer - Daham Kim
• Sex hormone-mediated regulation of ZBTB16 a candidate tumor suppressor in breast cancer - Maliha Wajahat
• A CRISPR-KO whole genome screen identifies factors and pathways that influence the tumour suppressive activity of androgen receptor agonist DHT in estrogen receptor positive breast cancer - Alex Pace
• Colon damage due to chemotherapy suppresses Vitamin D Receptor levels and is partially prevented by vitamin D analogue, VD1-6, in mice. - Paul H Anderson
• Investigating The Role Of Androgen Receptor Activation In Bladder Cancer - Ahmed F Aldoghachi

• The amazing osteocyte and its lacunar-canalicular network in health and disease - Katharina Jähn-Rickert

• LH regulation of steroidogenesis: coordinated actions of PKA in multiple organelles. - John Davis