Oral Presentation ESA-SRB-ANZBMS 2024 in conjunction with ENSA

Mass spectrometric analysis of corticosteroid binding globulin (CBG) in septic shock patients (#154)

Jessica (Hee Jong) Lee 1 2 , Zeynep Sumer-Bayraktar 3 , Parul Mittal 4 , Leigh Donnellan 4 , Clifford Young 4 , R. Louise Rushworth 5 , Marni Nenke 1 2 6 , Manuela Klingler-Hoffmann 4 , Peter Hoffmann 4 , Morten Thaysen-Andersen 3 7 , Emily Meyer 1 2 6 , David Torpy 1 2
  1. Department of Medicine, University of Adelaide, Adelaide, SA, Australia
  2. Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
  3. School of natural sciences, Macquarie University, Sydney, NSW, Australia
  4. Clinical and Health Sciences Unit, University of South Australia, Adelaide, SA, Australia
  5. School of Medicine, University of Notre Dame, Sydney, NSW, Australia
  6. Endocrine and Diabetes Unit, The Queen Elizabeth Hospital, Adelaide, SA, Australia
  7. Institute for Gloco-core Research, Nagoya University, Nagoya, Japan
Publish consent withheld
  1. 1. Meyer EJ, Nenke MA, Davies ML, Chapman M, Rankin W, Rushworth RL, Torpy DJ. Corticosteroid-Binding Globulin Deficiency Independently Predicts Mortality in Septic Shock. The Journal of clinical endocrinology and metabolism. 2022;107(6):1636-1646.
  2. 2. Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW. Hormone binding globulins undergo serpin conformational change in inflammation. Nature. 1988;336(6196):257-258.
  3. 3. Hill LA, Vassiliadi DA, Dimopoulou I, Anderson AJ, Boyle LD, Kilgour AHM, Stimson RH, Machado Y, Overall CM, Walker BR, Lewis JG, Hammond GL. Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma. The Journal of endocrinology. 2019;240(1):27-39.
  4. 4. Lewis JG, Elder PA. Intact or "active" corticosteroid-binding globulin (CBG) and total CBG in plasma: determination by parallel ELISAs using monoclonal antibodies. Clinica chimica acta; international journal of clinical chemistry. 2013;416:26-30.