Mei-Feng Chen
Mei-Feng Chen, PhD
Associate Research Fellow
Bone and Joint Research Center,
Chang Gung Memorial Hospital,
LINKOU Branch, Taoyuan County, Taiwan
E-mail: mfchen0@gmail.com
mfchen@cgmh.org.com
Overview
Over the past few years, I have led research in osteoarthritis (OA) and periprosthetic joint infection (PJI), focusing on elucidating physiological mechanisms, identifying novel therapeutic strategies for OA, and improving the accurate diagnosis of PJI for clinical applications. In the past five years, I have received five research grants from the National Science and Technology Council, Taiwan. I am a valuable Principal Investigator, known for my excellent judgment and mature outlook, resulting in logical and reliable research approaches.
My key achievements include:
1. Model Development: Established two OA mouse models: STR/ort and ACLT. Developed an evaluation method for spontaneous OA treatment in STR/ort mice.
2. Molecular Investigation: Explored the roles of EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) and platelet-derived growth factor receptor-like (PDGFRL) in cartilage integrity.
3. Innovation in MSC Production: Developed a cost-effective method for mesenchymal stem cell (MSC) production, facilitating technology transfer to a company. The Biologics License Application (BLA) has been submitted to the Taiwan Food and Drug Administration (TFDA) and is currently under review for product distribution approval.
4. PJI-Related Research: Focused on the diagnosis and treatment of PJI. Addressed the challenge of obtaining accurate preoperative predictions in the differential diagnosis of aseptic versus septic loosening. Surveyed novel factors in synovial fluid (SF) to improve PJI diagnosis and identified IL-16, IL-18, and CRELD2 as highly efficacious biomarkers. Demonstrated that SF tests outperform blood tests in accuracy and that these biomarkers can assess the success of debridement procedures.
5. Intellectual Property: Several patents are under review.
Selected Publications
1. Chen, M.F., Hu, C.C., Hsu Y.H., Lin, Y.C., Chen, K.L., Ueng, S.W.N., and Chang, Y. (2023). The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development: A potential novel therapy. Bone Joint Res, 12(12): 734-46. (First author, SCI, IF: 4.6, Orthopedics, Rank: 4/82)
2.Chen, M.F., Hu, C.C., Hsu, Y.H., Chiu, Y.T., Chen, K.L., Ueng, S.W.N., and Chang, Y. (2023). Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis. Biomedicines, 11(4), 1111. (First author, SCI, IF: 4.757)
3. Chang, C.H., Lee, S.H., Lin, Y.C., Hsu, C.Y., Cheng, C.C., Teng, S.H., Chen, M.F., Hsieh, P.H., Chang, Y., and Chiang-Ni, C. (2022). Characterization of the phenotypes of methicillin- and vancomycin-susceptible Staphylococcus argenteus after vancomycin passages. J Glob Antimicrob Resist 31, 63-71. 10.1016/j.jgar.2022.08.006.
4. Chang, Y., Hu, C.C., Wu, Y.Y., Ueng, S.W.N., Chang, C.H., and Chen, M.F. (2021) Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity. Int J Mol Sci 22. (Corresponding author, SCI, IF : 5.923, Biochemistry & Molecular Biology, Rank : 67/297 )
5. Chang, C.H., Hu, C.C., Chang, Y., Sia, K.C., Ueng, S.W.N., and Chen, M.F. (2020). Optimizing the Fracture Repair Mouse Model by Using Different Sizes of Femoral Defects. FASEB J 34, 1. (Corresponding author, SCI, IF : 4.97, Biology, Rank : 9/93 )
6. Huang, S.Y., Huang, C.H., Chen, C.J., Chen, T.W., Lin, C.Y., Lin, Y.T., Kuo, S.M., Huang, C.G., Lee, L.A., Chen, Y.H., Chen, M. F., Kuo, R. L., Shih, S. R. (2019). Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus. Mol Ther Nucleic Acids 17, 10-23. (SCI, IF :7.032, Medicine, Research & Experimental, Rank : 13/138 )
7. Chen, M.F., Chang, C.H., Yang, L.Y., Hsieh, P.H., Shih, H.N., Ueng, S.W.N., and Chang, Y. (2019). Synovial fluid interleukin-16, interleukin-18, and CRELD2 as novel biomarkers of prosthetic joint infections. Bone Joint Res 8, 179-188. (First author, SCI, IF: 5.853, Orthopedics, Rank: 4/82)
8. Chen, M.F., Chang, C.H., Hu, C.C., Wu, Y.Y., Chang, Y., and Ueng, S.W.N. (2019). Periprosthetic Joint Infection Caused by Gram-Positive Versus Gram-Negative Bacteria: Lipopolysaccharide, but not Lipoteichoic Acid, Exerts Adverse Osteoclast-Mediated Effects on the Bone. J Clin Med 8. (First author, SCI, IF: 4.241, Medicine,Genral& Internal, Rank: 39/169)
9. Chen, M.F., Chang, C.H., Chiang-Ni, C., Hsieh, P.H., Shih, H.N., Ueng, S.W.N., and Chang, Y. (2019). Rapid analysis of bacterial composition in prosthetic joint infection by 16S rRNA metagenomic sequencing. Bone Joint Res 8, 367-377. (First author, SCI, IF: 5.853, Orthopedics, Rank: 4/82)
10. Chen, M.F., Weng, K.F., Huang, S.Y., Liu, Y.C., Tseng, S.N., Ojcius, D.M., and Shih, S.R. (2017). Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections. Mucosal Immunol 10, 215-227. (First author, SCI, IF: 7.352, Immunology, Rank: 14/148)
11. Arthur Huang, K.Y., Chen, M.F., Huang, Y.C., Shih, S.R., Chiu, C.H., Lin, J.J., Wang, J.R., Tsao, K.C., and Lin, T.Y. (2017). Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children. Nat Commun 8, 762. (SCI, IF: 14.919, Multidisciplinary sciences, Rank: 6/71)
12. Chen, M.F., and Shih, S.R. (2016). Motor coordination and balance measurements reveal differential pathogenicity of currently spreading enterovirus 71 strains in human SCARB2 transgenic mice. J Gen Virol 97, 3243-3247. (First author, SCI, IF: 3.376, Biotechnology & Applied Microbiology Rank: 52/156)
13. Chen, M.F., Huang, T.Y., Kuo, Y.M., Yu, L., Chen, H.I., and Jen, C.J. (2013). Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice. J Physiol 591, 985-1000. (First author, SCI, IF: 5.182, Physiology Rank: 5/83)
14. Chen, M.F., Chen, H.I., and Jen, C.J. (2010). Exercise training upregulates macrophage MKP-1 and affects immune responses in mice. Med Sci Sports Exerc 42, 2173-2179. (First author, SCI, IF: 5.411, Sport sciences Rank:4/84)
15. Chang, Y.S., Tseng, S.Y., Tseng, S.H., Wu, C.L., and Chen, M.F. (2006). Triamcinolone acetonide suspension toxicity to corneal endothelial cells. J Cataract Refract Surg 32, 1549-1555.