Poster Presentation ESA-SRB-ANZBMS 2024 in conjunction with ENSA

Associations Between Muscle Mass and Strength AND Bone Microarchitecture In Caucasian Postmenopausal Women (#356)

Anoohya Gandham 1 2 , Alisa Turbic 1 , Marion Macrae 1 , Hadeel Nassar 1 , Liesbeth Vandenput 1 , Mattias Lorentzon 1 3
  1. Mary MacKillop Institute for Health Research , Australian Catholic University, Melbourne, Victoria, Australia
  2. Department of Medicine, Monash University, Clayton, Victoria, Australia
  3. Region Västra Götaland, Department of Orthopedics Sahlgrenska University Hospital, Mölndal, Sweden., Mölndal

Purpose: To investigate associations between sarcopenia components (muscle mass and strength) and bone microarchitecture in postmenopausal women.

Methods: Caucasian postmenopausal women (n=160) (mean ± standard deviation: 55.92 ± 2.63 years) not on hormonal replacement therapy or any other bone-related medications were included as part of baseline examination from the OsteoPreP Study. This study is a randomised controlled trial investigating the effects of 12 months of supplementation with a probiotic supplement on the relative change in bone microarchitecture measured using high resolution peripheral quantitative computed tomography (HR-pQCT) (https://clinicaltrials.gov/study/NCT05348694). Appendicular lean mass (ALM) was calculated as the sum of lean mass in the upper and lower limbs obtained from the dual-energy X-ray absorptiometry. Participants completed hand grip strength (HGS) using a dynamometer and the average of three measurements in the dominant hand was utilised. Cortical and trabecular bone microarchitecture parameters including volumetric bone mineral density (vBMD), thickness, and porosity were analysed by HR-pQCT (distal tibia and radius) at the standard and 30% sites. Linear regression (β-coefficients; p-value) analyses were performed with adjustments for age and smoking status.

Results: Higher appendicular lean mass index (ALMI; kg/m2) was significantly associated with greater total (13.886, <0.001) and cortical area (2.538; 0.002), and higher trabecular vBMD (9.661; 0.014), but with lower cortical vBMD (-12.203; 0.035) at the standard site (radius), after adjustment. Highly similar associations were observed at the 30% site (tibia). Higher HGS (kg) was significantly associated with greater total area and cortical area at the standard and 30% sites (radius and tibia) (all p<0.05), after adjustment.

Conclusion:

In summary, our investigation demonstrates that greater HGS is associated with augmented bone size whereas, greater ALMI is associated with augmented bone size, accompanied by diminished cortical bone density. This indicates that increased muscle mass is associated with larger bones, albeit at the expense of cortical vBMD.